Testing efficacy and maximising screening of limited cancerous tissue in 3D with ONCO-Chip3D technology
Our Services
Using proprietary microfluidic technology, ScreenIn3D provides next-generation, high quality screening services that help drug developers to validate the effectiveness of their compounds and treatment on physiologically relevant, preclinical in vitro models of disease. Our unique ONCO-Chip3D technology offers advanced and customisable drug screening assays using primary cells and human tissue in a 3D environment.
We Can:
Support
Offer you a full consultation service to identify the best service for you
Advice
Help you design and perform the most physiologically relevant experiments using state-of-the-art technology
Add Value
Assist you in deciding what are the best-endpoints to your scientific or clinical question
Collaborate
Provide anything from a one-off consultation to running all experiments in our dedicated facility
Our Advantages
We offer a robust, customisable, cost-efficient and medium-throughput 3D ex vivo assay service, which makes it possible to move away from the “one therapy fits all” approach and opens doors for precision medicine to tailor peoples’ individual treatment needs. The novel characteristics of our technology enable rapid decision making to prioritize the most promising drug candidates, biomarkers and drug combination strategies for preclinical drug discovery and development.
Large Throughput
Our microfluidic technology provides a data throughput up to 100 times larger than standard ultra-low-adhesion (ULA) plates for the same starting material. This enables a high number of replicates for your conditions of interest even when dealing with very small patient-derived samples, resulting in greater statistical significance and data that gives you confidence about drug efficacy.
Relevant Models
The disease microenvironment (e.g. tumour microenvironment-TME) affects the response of cells (e.g. cancer cells) to drugs. Mimicking these conditions in vitro using patient-derived 3D explants (i.e. tumoroids) provides data with a greater predictive value of drug efficacy in human studies than any other. Our technology allows screening of tumoroids, multicellular spheroids, organoids generated from biopsy tissues and primary cell lines, as well as advanced co-culture models.
Customer-defined Assays
Our platform is highly flexible and provides physiologically relevant 3D models tailored to your needs. We are able to customise many aspects of our assays, such as cell types, assay duration and readouts. By combining your specific knowledge with out expertise, we develop unique disease models to suit your requirements for drug development and evaluation.
High Quality Data
We offer a robust, cost-efficient screening service using a miniaturized and medium-throughput ex-vivo platform. Our technology achieves this even when working with extremely limited amounts of tumoroids (e.g. micro explants from human biopsies). This allows us to deliver multiparametric readouts with a high statistical relevance.
Cost-effective Assays
Custom ScreenIn3D services allow for cost and time reduction being associated with preclinical drug discovery while providing more relevant and useful information at the same time. Our microfluidic ONCO-Chip3D technology, through miniaturization and engineering know-how, enables to maximize the number of condition tested on precious, limited and unique human samples. For example, compared with 2D or 3D assays in a 96-well plate, we can achieve 10- up to 30- fold reduction in the use of cell material, media, regents and drugs.
